Definitive hematopoiesis in the yolk sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity

JM Frame, KH Fegan, SJ Conway, KE McGrath… - Stem …, 2016 - academic.oup.com
blood flow and oxygenation of the growing murine embryo [16, … This analysis revealed a
population of CD41 hi Kit neg cells … of the blood island region of the proximal yolk sac (above the …

Yolk sac hematopoiesis: does it contribute to the adult hematopoietic system?

V Wittamer, JY Bertrand - Cellular and molecular life sciences, 2020 - Springer
… These mouse blood islands, first described back to 1920 in … The clonal contribution of a
hemangioblast to a single blood … These early studies revealed that macrophages in various …

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

C Stremmel, R Schuchert, F Wagner, R Thaler… - Nature …, 2018 - nature.com
analyses of the YS revealed a CD16/… mouse anti-CD68 antibody (clone CL1346, Sigma,
1:1000), rabbit anti-CD68 antibody (polyclonal, Sigma, 1:1000), rabbit anti-CX 3 CR1 (polyclonal

[HTML][HTML] Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis

G Lacaud, V Kouskoff - Experimental hematology, 2017 - Elsevier
… In the developing mouse embryo, primitive hematopoiesis is most … yolk sac to generate a
clonal blood island. Nevertheless, one of the main conclusions in this study was that most blood

The development and maintenance of resident macrophages

EG Perdiguero, F Geissmann - Nature immunology, 2016 - nature.com
… morphology in blood islands of the yolk sac at embryonic day 9 (… , and clonal analysis of the
blood islands has revealed that … CSF1R and present in the early mouse embryo at E8.5, as …

Unveiling complexity and multipotentiality of early heart fields

Q Zhang, D Carlin, F Zhu, P Cattaneo, T Ideker… - Circulation …, 2021 - Am Heart Assoc
… lineage/clonal analyses, we show an unsuspected clonal relationship … by clonal analyses
in the mouse embryo, which revealed two … labeled clones in the heart and yolk sac at E9.5. E, …

Etv2 as an essential regulator of mesodermal lineage development

N Koyano-Nakagawa, DJ Garry - Cardiovascular research, 2017 - academic.oup.com
… induce the development of the blood island in yolk sacs. The … Etv2-EYFP transgenic embryo
reveals Etv2 expression in the … of the mouse embryo also resulted in abnormal yolk sac

[HTML][HTML] Interaction of the macrophage and primitive erythroid lineages in the mammalian embryo

J Palis - Frontiers in immunology, 2017 - frontiersin.org
… numbers within the yolk sac of the mouse embryo beginning at … erythroblastic islands from
E14.5 fetal livers also revealed late-… Clonal analysis identifies hemogenic endothelium as the …

Primitive erythrocytes are generated from hemogenic endothelial cells

M Stefanska, K Batta, R Patel, M Florkowska… - Scientific reports, 2017 - nature.com
murine embryogenesis, primitive erythroid (Ery/P) progenitors appear in the yolk sac blood
islands … potential, the results obtained with ES cells, and notably the presence of clonal blast …

[HTML][HTML] Pias1 is essential for erythroid and vascular development in the mouse embryo

JD Constanzo, M Deng, S Rindhe, K Tang… - Developmental …, 2016 - Elsevier
yolk sac (YS) blood islands approximately at embryonic (E) days 7.5–8.5. These nucleated
red blood cells begin circulating the embryo … This analysis revealed that Pias1 null embryonic …